Iga nephritis etiology
As the patient's skin and liver can be detected iga deposition, suggesting that systemic disease. Because in the glomerular mesangial area and capillaries can have granular iga and c3 deposition, suggesting that the immune complex pathogenesis. The current study revolves around the ability of the antigen to pass through the mucosa, whether the mucosal barrier is defective, whether the iga structure is defective, and whether the immunomodulatory function is defective. Early studies have suggested that iga deposited in this disease may be mucosal.
However, recent studies have used highly specialized techniques to confirm that the disease is iga1, mainly systemic, mainly produced by the bone marrow and lymphatic system; mucosal iga2 is mainly found in the liver Glial sclerosis in iga deposition. In the patients cycle can also be seen in the total iga1 and iga1-containing immune complex increased bone marrow iga1 produced by the increase in plasma cells and the formation of multi-polymer-based. In the kidney tissue of the disease can be found in the existence of j chain, it is prompted deposition of iga is a multimer; and secretion block is very rare. Nevertheless, the available information is not yet finalized to determine the source of the iga sediments of the disease.
Iga nephritis early symptoms
1, low back pain is a manifestation of symptoms of kidney disease, but usually the case of kidney disease patients often no obvious low back pain performance, or found that after the nausea feel faint back pain, that is sick waist, will feel back pain. In fact, this low back pain is not as pyelonephritis and kidney stones back pain, kidney nephritis more than one side of the low back pain, and kidney stones, low back pain performance and more to the thigh medial radiation.
2, hematuria is divided into two, that is, gross hematuria and microscopic hematuria, microscopic hematuria is not visible with the naked eye, only in the microscope only red blood cells. If there is naked eye hematuria that there are a lot of urine inside the red blood cells.
3, abnormal normal urine color is transparent yellow, if less water or early morning urination, the color is slightly deeper. If the urine redness, or urine foam, pay attention to the Department of renal medicine examination.
4, swollen kidneys is the body's metabolism of water organs, kidney is not good, the water will accumulate. Some people in the morning to find eyelid edema, or feet, legs swollen, have to consider the kidney problem. Specific swelling of the performance of the eyelids, facial, scrotum and other relatively loose central, the current will appear lower extremity edema, tension can also be systemic edema, a few people may have ascites.
Iga nephritis care precautions
1, limiting salt edema and blood volume, sodium salt great relationship. Every 1 gram of salt can bring about 110 ml of water, nephritis patients such as eating too much salt, and voiding function and damage, often aggravate the symptoms of edema, increased blood volume, resulting in heart failure, so chronic glomerulonephritis must be limited Salt, given low salt diet. Daily salt intake should be controlled in 2-4 grams below, to prevent increased edema and increased blood volume, accidents.
2, the system contains high purine and high nitrogen foods: In order to reduce the burden on the kidneys, should limit the stimulation of kidney cell food, such as spinach, celery, radish, beans, soy products, sardines and chicken soup, fish soup, broth Wait.
3, strong condiments: strong spices such as pepper, mustard, gallbladder, pepper and other adverse renal function, should not eat. MSG because of more food will be thirsty to drink, in limiting the amount of water, it should be less use MSG.
4, plant protein protein intake should be depending on the renal function may be. Control protein intake, can also achieve the purpose of low phosphorus, the general daily 0.6 g / kg body weight, of which half of high-quality protein (rich in essential amino acid protein), such as eggs, lean meat, milk and so on.
As the patient's skin and liver can be detected iga deposition, suggesting that systemic disease. Because in the glomerular mesangial area and capillaries can have granular iga and c3 deposition, suggesting that the immune complex pathogenesis. The current study revolves around the ability of the antigen to pass through the mucosa, whether the mucosal barrier is defective, whether the iga structure is defective, and whether the immunomodulatory function is defective. Early studies have suggested that iga deposited in this disease may be mucosal.
However, recent studies have used highly specialized techniques to confirm that the disease is iga1, mainly systemic, mainly produced by the bone marrow and lymphatic system; mucosal iga2 is mainly found in the liver Glial sclerosis in iga deposition. In the patients cycle can also be seen in the total iga1 and iga1-containing immune complex increased bone marrow iga1 produced by the increase in plasma cells and the formation of multi-polymer-based. In the kidney tissue of the disease can be found in the existence of j chain, it is prompted deposition of iga is a multimer; and secretion block is very rare. Nevertheless, the available information is not yet finalized to determine the source of the iga sediments of the disease.
Iga nephritis early symptoms
2, hematuria is divided into two, that is, gross hematuria and microscopic hematuria, microscopic hematuria is not visible with the naked eye, only in the microscope only red blood cells. If there is naked eye hematuria that there are a lot of urine inside the red blood cells.
3, abnormal normal urine color is transparent yellow, if less water or early morning urination, the color is slightly deeper. If the urine redness, or urine foam, pay attention to the Department of renal medicine examination.
4, swollen kidneys is the body's metabolism of water organs, kidney is not good, the water will accumulate. Some people in the morning to find eyelid edema, or feet, legs swollen, have to consider the kidney problem. Specific swelling of the performance of the eyelids, facial, scrotum and other relatively loose central, the current will appear lower extremity edema, tension can also be systemic edema, a few people may have ascites.Iga nephritis care precautions
1, limiting salt edema and blood volume, sodium salt great relationship. Every 1 gram of salt can bring about 110 ml of water, nephritis patients such as eating too much salt, and voiding function and damage, often aggravate the symptoms of edema, increased blood volume, resulting in heart failure, so chronic glomerulonephritis must be limited Salt, given low salt diet. Daily salt intake should be controlled in 2-4 grams below, to prevent increased edema and increased blood volume, accidents.
2, the system contains high purine and high nitrogen foods: In order to reduce the burden on the kidneys, should limit the stimulation of kidney cell food, such as spinach, celery, radish, beans, soy products, sardines and chicken soup, fish soup, broth Wait.
3, strong condiments: strong spices such as pepper, mustard, gallbladder, pepper and other adverse renal function, should not eat. MSG because of more food will be thirsty to drink, in limiting the amount of water, it should be less use MSG.
4, plant protein protein intake should be depending on the renal function may be. Control protein intake, can also achieve the purpose of low phosphorus, the general daily 0.6 g / kg body weight, of which half of high-quality protein (rich in essential amino acid protein), such as eggs, lean meat, milk and so on.
评论
发表评论