This article to you in detail about the linear IgA bullous skin disease pathology, linear IgA bullous skin disease is mainly caused by what causes.
First, the cause of linear IgA bullous skin disease
First, the cause of the disease
Etiology is not clear, and that the current autoimmune factors.
Second, the pathogenesis
Since the dermal binding of the basement membrane is linear IgA deposition, whereas IgA is secreted immunoglobulin, it has not yet been able to determine its origin. Indirect immunofluorescence found that circulating IgA antibody against basement membrane was located on the epidermis side of saline, and a few studies reported that the antigen was located on the dermal side, indicating that the target antigen of the disease may be more than one. Immunoelectron microscopy revealed that there were three types of antibodies to the linear IgA skin disease, one deposited on the transparent plate, the other being deposited on the dense plate and below, and the third being above and below the dense plate. IgA deposition in children with chronic bullous skin disease is also located in the transparent plate, dense plate and below it. These findings further support multiple antigens involved in target antigen as a linear and IgA deposition for adults and children. The preliminary study found that the antigenic molecular weight of 97kDa, 285kDa and 120kDa three kinds of protein. The above studies have shown that linear IgA bullous skin diseases and children with chronic bullous skin disease have many common antigens, the detailed mechanism to be further studied.
Taking certain drugs such as vancomycin, lithium preparations can cause the occurrence of the disease, withdrawal after the disease remission, re-use of such drug recurrence, drug-induced minor illness mechanism is not clear, but it is clear that some drugs may cause IgA deposition in the skin leading to the occurrence of the disease.
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