What checks should children do IgA nephropathy?

Children with IgA nephropathy common examination:
Common examination: urinary occult blood (BLD), urinary protein, circulating immune complex (CIC)

First, urine test

(1) hematuria: clinically about 40% to 45% of the patients showed gross or microscopic hematuria, 35% to 40% of patients with simple microscopic hematuria, or microscopic hematuria with a small amount of proteinuria. Naked eye hematuria can be sustained for several hours to several days, after the conversion to persistent microscopic hematuria, some patients can disappear, but often attack, the recurrence of nausea hematuria.

(2) proteinuria: mild proteinuria, the general urine protein quantitative <1g / 24h, a small number of patients may be a large number of proteinuria and even nephrotic syndrome.

2, immunological examination (1) IgA increased: about 1/4 ~ l / 2 patients with elevated blood IgA, mainly increased the number of polymer IgA.

(2) circulating immune complex: about 1/5 ~ 2/3 children with blood can be detected IgA immune complexes and / or IgG circulating immune complexes.

(3) anti-"O" increased: a small number of patients with anti-"O" titer increased.

(4) complement: C3, C4 more normal.

(5) Other: IgA type rheumatoid factor and IgA type ANCA is also often positive, it was thought that elevated blood IgA-fibronectin complex is IgA nephropathy characteristic change, has a high diagnostic value. If necessary, do B ultrasound, ECG and X-ray examination. Immunopathological examination: renal immune pathology is the only key basis for the diagnosis of IgA nephropathy. Some people on the skin immunopathological examination found that 20% to 50% of the patient's skin capillary wall IgA, C3, the deposition of progesterone, Bene and other reports of skin biopsy specificity and sensitivity were 88% and 75% The

The above is for children with IgA nephropathy should do what the relevant aspects of the relevant description of the following look at how children should be differential diagnosis of IgA nephropathy, children with IgA kidney disease easy to confuse the disease.

How does IgA nephropathy identify? :

One, identification

Should be excluded from other causes of hematuria, such as urinary tract damage, hypercalciuria, stones, tuberculosis, familial benign hematuria, Alport syndrome, acute exacerbation of chronic nephritis and so on. In the immune pathology was IgA calm, should pay attention to a variety of other systemic diseases can also be presented when the glomerular IgA calm (this is the secondary IgA nephropathy). The common reasons are as follows:

1, systemic multi-system disease allergic purpura, systemic lupus erythematosus, chronic liver disease, Crohn's disease, herpes-like dermatitis, ankylosing spondylitis.

2, infectious diseases, mycoplasma infection, toxoplasmosis, hepatitis virus and so on. 3. Other thrombocytopenia, cryoglobulinemia, polycythemia, non-Hodgkin's lymphoma, scleritis, certain intestinal or lung cancer. The above situation can be identified by means of other performance.