IgA nephritis, clinical also known as "Berger disease", "IgA mesangial nephritis", for our country's most common primary glomerular disease, accounting for about one-third of primary glomerulonephritis. ...
What is IgA nephritis?
IgA nephritis, clinical also known as "Berger disease", "IgA mesangial nephritis", for our most common primary glomerular disease, accounting for about one-third of primary glomerulonephritis. IgA nephritis nephropathy in patients with renal mesangial area extensive deposition of IgA, IGG immune complex, resulting in increased mesangial cells, mesangial stromal hyperplasia, hence the name of the above-mentioned IgA nephritis pathology seen by the pathology, so by renal puncture Biopsy can be diagnosed with IgA nephritis.
IgA nephritis more common in children and young people, 30 years of age IgA nephritis patients account for about 80% of the total incidence, and male to female ratio of 2: 1.
What are the clinical manifestations of typical IgA nephritis?
Typical clinical manifestations of IgA nephritis in patients with recurrent nausea hematuria or microscopic hematuria. Usually, these patients in the upper respiratory tract infection (that is, often say cold, tonsil inflammation, etc.) after a few hours to two days of gross hematuria, hematuria will continue for several hours to several days, individual patients up to more than a week. Such IgA nephritis patients account for about 40% to 45% of the total. In addition, about 35% to 40% of IgA nephritis patients with clinical manifestations of microscopic hematuria with proteinuria symptoms.
How is treatment treated with IgA nephritis?
Want to know how effective treatment of IgA nephritis in order to avoid the disease repeated, first of all should understand how IgA nephritis disease occurs.
Most IgA nephropathy is due to colds, infection incentives began to appear under the onset of hematuria. When the cold, the cold virus will invade the resistance has been very low population, destruction of its immune regulation function, making the body mucosa secretion of large amounts of immunoglobulin IgA and abnormal deposition in the renal mesangial area and renal capillaries. In addition, invasive viruses and in vivo globulin bind to a large number of immune complexes deposited in the kidney. Abnormal accumulation of these IgA immune complexes in the kidney will lead to changes in the intrinsic cell function within the kidney, increased mesangial cells, mesangial stromal hyperplasia, and a large number of electron dense aggregates in the mesangial area. This is the common pathogenesis of kidney disease - the initiation of renal fibrosis. Renal fibrosis caused the kidneys of glomerular filtration barrier damage, which will have a lot of protein and red blood cells leak, the clinical manifestations of urine protein, hematuria symptoms.
Often, IgA nephropathy in the presence of a cold precursor to the premise of the first occurrence of gross hematuria, clinical majority will indicate the disease began to occur. IgA nephritis patients with nausea hematuria will be recurrent, ranging from 1 to 20 times, and each episode of the interval will increase with the increase in the number of episodes, while IgA nephropathy recurrence once, patients with renal fibrosis The degree will increase a point, the kidney disease will become more serious.
How to effectively treat IgA nephritis? After the application of Western medicine, the symptoms may disappear in the short term, but in the presence of incentives, the symptoms will come back again and again. Proper and effective treatment needs to proceed from the root of the disease - kidney fibrosis. Through effective means to block renal fibrosis of IgA nephritis treatment, fundamentally remove the IgA nephritis factors. At the same time, the fibrosis has been the occurrence of renal tissue in the correct treatment, repair leakage of red blood cells, protein glomerular filtration barrier. In this way, on the one hand to remove the risk factors, on the other hand to repair the damaged kidneys, "two-pronged", so as to effectively prevent the recurrence of the disease, will also be able to effectively prevent IgA nephropathy continue to deteriorate progress to renal failure stage.
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